Q&A: The risks of brain bleeds in antibody treatments for Alzheimer’s disease

Ryan Institute Co-Executive Director William Van Nostrand answers questions about the potential risk of brain bleeds associated with newly-approved lecanemab and similar treatments. This summer, the FDA granted full approval to lecanemab, an antibody treatment for Alzheimer’s disease.  The antibody—a protein that works by clearing amyloid-beta protein “plaques” in the brain, a signature of Alzheimer’s disease—has […]

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New affiliated faculty members join the Ryan Institute

The Ryan Institute was pleased to welcome ten new faculty affiliates in Spring 2023 from the College of Pharmacy, College of Health Sciences, and College of Electrical, Computer, and Biomedical Engineering. Specializing in research areas that complement the institute’s focus on pathogenic mechanisms of neurodegenerative disease, our URI network of affiliated faculty are valuable partners […]

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Graduate Students Receive Top Awards at Neuron 2023

April 27, 2023 URI neuroscience graduate students Emily Potts and Michelle Gregoire received awards at the Neuron 2023 research conference at Quinnipiac University’s Frank H. Netter MD School of Medicine on Sunday, April 23. The event was co-sponsored by the University of Connecticut. Students from the labs of Ryan Institute assistant professors Claudia Fallini and […]

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Looking to spinal motor neurons to investigate the mysteries of ALS

Using his unique in vivo approach, Assistant Professor Marin Manuel investigates electrical activity in the spinal motor neurons in a disease model of amyotrophic lateral sclerosis. Also known as Lou Gehrig’s disease, amyotrophic lateral sclerosis (ALS) is a mysterious and fatal disorder where nerve cells in the brain and spinal cord break down, rapidly progressing […]

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Q&A: Giuseppe Coppotelli, Ph.D.

Giuseppe Coppotelli, Ph.D. investigates how protein homeostasis deregulation and mitochondrial dysfunction in the aging brain could contribute to chronic inflammation and dementias such as Alzheimer’s disease. What drew you to this area of research?Growing up, I was always curious about living organisms. How do plants grow? How do they know to turn their leaves to […]

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Q&A with Joseph Schrader, Ph.D.

Joe Schrader, research assistant professor of biomedical and pharmaceutical sciences, uses mass spectroscopy proteomics to investigate biomarkers and disease mechanisms in Alzheimer’s disease and related disorders. He shares his thoughts on research, how being a musician makes him a better scientist, and why he hasn’t missed a day of running in seven years. What drew […]

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