Manuel News

    October 2024 Emily Reedich presented results from her work with the Manuel lab at the Society for Neuroscience annual meeting in Chicago: “This year, the SfN Annual Meeting drew more than 20,000 attendees,” said Reedich, who also presented a poster with the Ryan Institute’s Quinlan lab. “The breadth of neuroscience research presented at […]

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Manuel Publications

  Publications *Ryan Institute affiliation Nascimento, Filipe, M. Görkem Özyurt, Kareen Halablab, Gardave Singh Bhumbra, Guillaume Caron, Marcin Bączyk, Daniel Zytnicki, et al. Spinal Microcircuits Go through Multiphasic Homeostatic Compensations in a Mouse Model of Motoneuron Degeneration. Cell Reports 43, no. 12, 2024.  Reedich EJ,* Genry LT,* Steele PR,* Mena Avila E,* Dowaliby L,* Drobyshevsky A, […]

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Manuel Overview

  The Manuel Lab focuses on unraveling the intricacies of the motor system and understanding how normal motor function is impacted in pathological conditions. Employing a range of cutting-edge techniques, including in vivo electrophysiology, in vitro electrophysiology, viral approaches, and advanced imaging methods, our research aims to shed light on the underlying mechanisms governing motor […]

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Q&A: Jessica Alber, Ph.D.

Her inspiration, the biggest challenges in her work, and what makes her feel hopeful. Assistant Professor Jessica Alber investigates the potential to use retinal imaging as a screening tool for early-stage Alzheimer’s disease. Performed during a routine eye exam, the screening technique could help provide a low-cost, minimally invasive way to detect Alzheimer’s disease before […]

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Q&A: The risks of brain bleeds in antibody treatments for Alzheimer’s disease

Ryan Institute Co-Executive Director William Van Nostrand answers questions about the potential risk of brain bleeds associated with newly-approved lecanemab and similar treatments. This summer, the FDA granted full approval to lecanemab, an antibody treatment for Alzheimer’s disease.  The antibody—a protein that works by clearing amyloid-beta protein “plaques” in the brain, a signature of Alzheimer’s disease—has […]

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