ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function. Baron DM et al (incl Fallini C.*). Cell Reports. April 2022.  Traffic jam at the nuclear pore: All roads lead to nucleocytoplasmic transport defects in ALS/FTD. Fallini C, Khalil B, Smith CL, Rossol W. Neurobiology of Disease, July 2020. ScienceDirect. Modulation […]

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  The overarching goal of the Fallini Lab is to dissect the molecular and cellular changes that occur in postmitotic neurons during aging and in pathological conditions, such as Amyotrophic Lateral Sclerosis, Frontotemporal Dementia (ALS/FTD) and Alzheimer’s disease. Our current research is focused on investigating the crosstalk between the actin cytoskeleton, a regulator of cell […]

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  Is there a link among the pathogenic mechanisms associated with neurodegenerative disease? Multiple pathways have been identified as playing a role in the development and progression of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), but it is unclear how they are connected.  Our current research investigates the role of the actin cytoskeleton –– […]

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Ross Overview

The Ross Lab investigates fundamental questions of aging. Our primary objectives are directed toward understanding the metabolic consequences and underlying molecular mechanisms of aging and age-related diseases, with a particular focus on brain aging and neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. Our work investigates the interconnectedness of several hallmarks of the aging process: mitochondrial […]

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Ross Biography

Jaime M. Ross, Ph.D. joined the URI Faculty in October 2019 and is an Assistant Professor of Neuroscience within the George and Anne Ryan Institute for Neuroscience and Biomedical and Pharmaceutical Sciences in the College of Pharmacy. Dr. Ross is a native of Southern Vermont and attended Saint Lawrence University, where she studied Neuroscience and Fine Arts. Dr. […]

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Ross Publications

    (♯) Corresponding author(†) signifies trainees Select Publications Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model. Ross JM*, Olson L, Coppotelli G*. MDPI, January 2024. Gaspar L*, Bartman S*, Coppotelli G*, Ross J*. Effect of apparatus characteristics on anxiety-like behavior in young adult and old mice of both sexes […]

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