Using his unique in vivo approach, Assistant Professor Marin Manuel investigates electrical activity in the spinal motor neurons in a disease model of amyotrophic lateral sclerosis. Also known as Lou Gehrig’s disease, amyotrophic lateral sclerosis (ALS) is a mysterious and fatal disorder where nerve cells in the brain and spinal cord break down, rapidly progressing […]

Giuseppe Coppotelli, Ph.D. investigates how protein homeostasis deregulation and mitochondrial dysfunction in the aging brain could contribute to chronic inflammation and dementias such as Alzheimer’s disease. What drew you to this area of research?Growing up, I was always curious about living organisms. How do plants grow? How do they know to turn their leaves to […]

Assistant Professor Jaime Ross investigates fundamental questions of aging. In this Q&A, she shares her thoughts on the questions that drive her research and what she finds most encouraging about the aging process. How did you become interested in studying aging?It happened by accident. I was studying a robust model of premature aging developed at […]

(♯) Corresponding author(†) signifies trainees Adelöf J, Ross JM, Zetterberg M, Hernebring M. (2021). Survival-Span Method: How to Qualitatively Estimate Lifespan to Improve the Study of Aging, and not Disease, in Aging Studies. Frontiers in Aging, Dec 2021. Potts E†, Coppotelli G, Ross JM#. (July 2020) Histological-based stainings using free-floating method. Journal of Visualized Experiments. […]

  In the News Additional Lab Highlights August 2024 Drs. Ross and Coppotelli received a two-year, $433,125 NIH grant to characterize a new mouse model of mitochondrial dysfunction. The model will allow researchers to isolate mtDNA mutations within single tissues to more accurately understand the impacts on different health and disease states. June 2024 RI-INBRE […]

    September 2023. The Fallini lab received a $413,729 NIH grant to study the link between stroke and Alzheimer’s disease.  April 2023. Students in the Fallini lab participated in the Neuron 2023 Conference at Quinnipiac University, taking home top awards.

    Dr. Fallini received her Ph.D. from the Università degli Studi di Milano (Italy) in 2009, where she gained interest in the basic cellular and molecular mechanisms leading to neurodegeneration, with a particular focus on the role of mRNA regulation in the maintenance and function of motor neurons.   After she graduated, she moved […]

  Early disruption of the CREB pathway drives dendritic morphological alterations in FTD/ALS cortical neurons. Gregoire MJ, Sirtori R, Donatelli L, Potts EM, Collins A, Zamor D, Katenka N, Fallini C. Journal of the Proceedings of the National Academy of Sciences, December 2024 LINC complex alterations are a key feature of sporadic and familial ALS/FTD. […]