(♯) Corresponding author(†) signifies trainees Adelöf J, Ross JM, Zetterberg M, Hernebring M. (2021). Survival-Span Method: How to Qualitatively Estimate Lifespan to Improve the Study of Aging, and not Disease, in Aging Studies. Frontiers in Aging, Dec 2021. Potts E†, Coppotelli G, Ross JM#. (July 2020) Histological-based stainings using free-floating method. Journal of Visualized Experiments. […]

  In the News Additional Lab Highlights August 2024 Drs. Ross and Coppotelli received a two-year, $433,125 NIH grant to characterize a new mouse model of mitochondrial dysfunction. The model will allow researchers to isolate mtDNA mutations within single tissues to more accurately understand the impacts on different health and disease states. June 2024 RI-INBRE […]

    September 2023. The Fallini lab received a $413,729 NIH grant to study the link between stroke and Alzheimer’s disease.  April 2023. Students in the Fallini lab participated in the Neuron 2023 Conference at Quinnipiac University, taking home top awards.

    Dr. Fallini received her Ph.D. from the Università degli Studi di Milano (Italy) in 2009, where she gained interest in the basic cellular and molecular mechanisms leading to neurodegeneration, with a particular focus on the role of mRNA regulation in the maintenance and function of motor neurons.   After she graduated, she moved […]

  Early disruption of the CREB pathway drives dendritic morphological alterations in FTD/ALS cortical neurons. Gregoire MJ, Sirtori R, Donatelli L, Potts EM, Collins A, Zamor D, Katenka N, Fallini C. Journal of the Proceedings of the National Academy of Sciences, December 2024 LINC complex alterations are a key feature of sporadic and familial ALS/FTD. […]

  The overarching goal of the Fallini Lab is to dissect the molecular and cellular changes that occur in postmitotic neurons during aging and in pathological conditions, such as Amyotrophic Lateral Sclerosis, Frontotemporal Dementia (ALS/FTD) and Alzheimer’s disease. Our current research is focused on investigating the crosstalk between the actin cytoskeleton, a regulator of cell […]

  Is there a link among the pathogenic mechanisms associated with neurodegenerative disease? Multiple pathways have been identified as playing a role in the development and progression of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), but it is unclear how they are connected.  Our current research investigates the role of the actin cytoskeleton –– […]

The Ross Lab investigates fundamental questions of aging. Our primary objectives are directed toward understanding the metabolic consequences and underlying molecular mechanisms of aging and age-related diseases, with a particular focus on brain aging and neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. Our work investigates the interconnectedness of several hallmarks of the aging process: mitochondrial […]