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Manuel Publications

  Publications *Ryan Institute affiliation Reedich EJ,* Genry LT,* Steele PR,* Mena Avila E,* Dowaliby L,* Drobyshevsky A, Manuel M,* Quinlan KA.* Spinal Motoneurons Respond Aberrantly to Serotonin in a Rabbit Model of Cerebral Palsy.  J Physiol., 2023.  Cavarsan CF,* Steele PR,* Genry LT,* Reedich EJ,* McCane LM,* LaPre KJ,* Puritz AC,* Manuel M,* Katenka N, Quinlan […]

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Manuel Overview

  The Motor Systems Lab focuses on unraveling the intricacies of the motor system and understanding how normal motor function is impacted in pathological conditions. Employing a range of cutting-edge techniques, including in vivo electrophysiology, in vitro electrophysiology, viral approaches, and advanced imaging methods, our research aims to shed light on the underlying mechanisms governing […]

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Q&A: Jessica Alber, Ph.D.

Her inspiration, the biggest challenges in her work, and what makes her feel hopeful. Assistant Professor Jessica Alber investigates the potential to use retinal imaging as a screening tool for early-stage Alzheimer’s disease. Performed during a routine eye exam, the screening technique could help provide a low-cost, minimally invasive way to detect Alzheimer’s disease before […]

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Q&A: The risks of brain bleeds in antibody treatments for Alzheimer’s disease

Ryan Institute Co-Executive Director William Van Nostrand answers questions about the potential risk of brain bleeds associated with newly-approved lecanemab and similar treatments. This summer, the FDA granted full approval to lecanemab, an antibody treatment for Alzheimer’s disease.  The antibody—a protein that works by clearing amyloid-beta protein “plaques” in the brain, a signature of Alzheimer’s disease—has […]

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