The Manuel Lab

Room 465, Beaupre Center for Chemical & Forensic Sciences


*Ryan Institute affiliation

Reedich EJ,* Genry LT,* Steele PR,* Mena Avila E,* Dowaliby L,* Drobyshevsky A, Manuel M,* Quinlan KA.* Spinal Motoneurons Respond Aberrantly to Serotonin in a Rabbit Model of Cerebral Palsy.  J Physiol., 2023. 

Cavarsan CF,* Steele PR,* Genry LT,* Reedich EJ,* McCane LM,* LaPre KJ,* Puritz AC,* Manuel M,* Katenka N, Quinlan KA. Inhibitory Interneurons Show Early Dysfunction in a SOD1 Mouse Model of Amyotrophic Lateral Sclerosis. J Physiol., 2023. 

França de Barros F, Bacqué-Cazenave J, Taillebuis C, Courtand G, Manuel M*, Bras H, Tagliabue M, Combes D, Lambert FM, Beraneck M. Conservation of locomotion-induced oculomotor activity through evolution in mammals. Curr Biol. 2022 Jan 24;32(2):453-461.e4. doi: 10.1016/j.cub.2021.11.022

Manuel M, Zytnicki D. Comments on the article by Jensen et al. (2020). J Physiol. 2021 Sep;599(17):4231-4232. doi: 10.1113/JP281461

Huh S, Heckman CJ, Manuel M. Time Course of Alterations in Adult Spinal Motoneuron Properties in the SOD1(G93A) Mouse Model of ALS. eNeuro. 2021 Mar-Apr;8(2). doi: 10.1523/ENEURO.0378-20.2021

Manuel M. Suboptimal Discontinuous Current-Clamp Switching Rates Lead to Deceptive Mouse Neuronal Firing. eNeuro. 2021 Jan-Feb;8(1). doi: 10.1523/ENEURO.0461-20.2020

Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D. Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS. J Exp Med. 2020 Aug 3;217(8). doi: 10.1084/jem.20191734

Manuel M, Zytnicki D. Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes. Curr Opin Physiol. 2019 Apr;8:23-29. doi: 10.1016/j.cophys.2018.11.008

Manuel M, Chardon M, Tysseling V, Heckman CJ. Scaling of Motor Output, From Mouse to Humans. Physiology (Bethesda). 2019 Jan 1;34(1):5-13. doi: 10.1152/physiol.00021.2018

Martínez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M. Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS. Elife. 2018 Mar 27;7. doi: 10.7554/eLife.30955

Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F. Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion. Cell Rep. 2018 Mar 20;22(12):3315-3327

Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C. Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve. Sci Rep. 2018 Feb 6;8(1):2524. doi: 10.1038/s41598-018-20980-3 

Tysseling VM, Klein DA, Imhoff-Manuel R, Manuel M, Heckman CJ, Tresch MC. Constitutive activity of 5-HT(2C) receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment. J Neurophysiol. 2017 Nov 1;118(5):2944-2952. doi: 10.1152/jn.00190.2017

Huh S, Siripuram R, Lee RH, Turkin VV, O’Neill D, Hamm TM, Heckman CJ, Manuel M. PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species. J Neurophysiol. 2017 Jul 1;118(1):93-102. doi: 10.1152/jn.00045.2017

Meehan CF, Mayr KA, Manuel M, Nakanishi ST, Whelan PJ. Decerebrate mouse model for studies of the spinal cord circuits. Nat Protoc. 2017 Apr;12(4):732-747. doi: 10.1038/nprot.2017.001

Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016 May;3(5):331-45. doi: 10.1002/acn3.298

Messéant J, Dobbertin A, Girard E, Delers P, Manuel M, Mangione F, Schmitt A, Le Denmat D, Molgó J, Zytnicki D, Schaeffer L, Legay C, Strochlic L. MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance. J Neurosci. 2015 Mar 25;35(12):4926-41. doi: 10.1523/JNEUROSCI.3381-14.2015.   

Ritter LK, Tresch MC, Heckman CJ, Manuel M, Tysseling VM. Characterization of motor units in behaving adult mice shows a wide primary range. J Neurophysiol. 2014 Aug 1;112(3):543-51. doi: 10.1152/jn.00108.2014

Delestrée N, Manuel M, Iglesias C, Elbasiouny SM, Heckman CJ, Zytnicki D. Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis. J Physiol. 2014 Apr 1;592(7):1687-703. doi: 10.1113/jphysiol.2013.265843

Manuel M, Zytnicki D, Meunier C. The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons. Front Comput Neurosci. 2014;8:4. doi: 10.3389/fncom.2014.00004

Manuel M, Heckman CJ. Simultaneous intracellular recording of a lumbar motoneuron and the force produced by its motor unit in the adult mouse in vivo. J Vis Exp. 2012 Dec 5;(70):e4312. doi: 10.3791/4312

Manuel M, Li Y, Elbasiouny SM, Murray K, Griener A, Heckman CJ, Bennett DJ. NMDA induces persistent inward and outward currents that cause rhythmic bursting in adult rodent motoneurons. J Neurophysiol. 2012 Dec;108(11):2991-8. doi: 10.1152/jn.00518.2012 

Johnson MD, Hyngstrom AS, Manuel M, Heckman CJ. Push-pull control of motor output. J Neurosci. 2012 Mar 28;32(13):4592-9. doi: 10.1523/JNEUROSCI.4709-11.2012

Manuel M, Heckman CJ. Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment? J Neurosci. 2011 Oct 19;31(42):15188-94. doi: 10.1523/JNEUROSCI.2893-11.2011

Manuel M, Zytnicki D. Alpha, beta and gamma motoneurons: functional diversity in the motor system’s final pathway. J Integr Neurosci. 2011 Sep;10(3):243-76. doi: 10.1142/S0219635211002786

Frigon A, Thompson CK, Johnson MD, Manuel M, Hornby TG, Heckman CJ. Extra forces evoked during electrical stimulation of the muscle or its nerve are generated and modulated by a length-dependent intrinsic property of muscle in humans and cats. J Neurosci. 2011 Apr 13;31(15):5579-88. doi: 10.1523/JNEUROSCI.6641-10.2011

Iglesias C, Meunier C, Manuel M, Timofeeva Y, Delestrée N, Zytnicki D. Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state. J Neurosci. 2011 Apr 13;31(15):5829-40. doi: 10.1523/JNEUROSCI.6363-10.2011

Manuel M, Heckman CJ. Stronger is not always better: could a bodybuilding dietary supplement lead to ALS? Exp Neurol. 2011 Mar;228(1):5-8. doi: 10.1016/j.expneurol.2010.12.007

Manuel M, Iglesias C, Donnet M, Leroy F, Heckman CJ, Zytnicki D. Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons. J Neurosci. 2009 Sep 9;29(36):11246-56. doi: 10.1523/JNEUROSCI.3260-09.2009 

Manuel M, Meunier C, Donnet M, Zytnicki D. Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons. J Neurosci. 2007 Nov 21;27(47):12977-88. doi: 10.1523/JNEUROSCI.3299-07.2007

Manuel M, Meunier C, Donnet M, Zytnicki D. The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats. J Physiol. 2006 Nov 1;576(Pt 3):873-86. doi: 10.1113/jphysiol.2006.117002