The Fallini Lab

Department of Cell & Molecular Biology

 

 

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function. Baron DM et al (incl Fallini C.*). Cell Reports. April 2022. 

Traffic jam at the nuclear pore: All roads lead to nucleocytoplasmic transport defects in ALS/FTD. Fallini C, Khalil B, Smith CL, Rossol W. Neurobiology of Disease, July 2020. ScienceDirect.

Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis. Giampetruzzi A, Danielson EW, Gumina V, Jeon M, Boopathy S, Brown RH, Ratti A, Landers JE, Fallini C. Modulation of actin polymerization affects nucleocytoplasmic transport in the multiple forms of amyotrophic lateral sclerosis. Nature Communications, 2019; 10:3827. PubMed.