Selected Publications
Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy. Robison SL, Popescu DL*, Anderson ME, Francis N, Hatfield J, Sullivan JK, Beigelman SI, Xu F*, Anderson BJ, Van Nostrand WE*, Robinson JK*. Journal of Neuroinflammation, July 2019. PubMed.
Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu Y-Y, Zeldich D, Xia W, Van Nostrand WE*, Brown LE, Porco JA, Abrahama CR. Journal of Alzheimer’s Disease, July 2019. PubMed.
A novel transgenic rat model of robust cerebral miscrovascular amyloid with prominent vasculopathy. Davis, J*, Xu, F*, Hatfield, J*, Lee H., Hoos, M.D., Popescu, D, Crooks, E., Kim, R*, Smith, S.O., Robinson, JK*, Benveniste, H., and Van Nostrand, WE* American Journal of Pathology 188:2877-2889, December 2018. PubMed.
Intensive “brain training” intervention fails to reduce amyloid pathologies or cognitive deficits in transgenic mouse models of Alzheimer’s disease. Anderson, M, Xu, F*, Ou-Yang, MH, Davis, J*, Van Nostrand, WE*, and Robinson, JK.* Journal of Alzheimer’s Disease 55:1109-1121(2017). PMID: 27767989
Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid b-protein precursor abolishes its anti-thrombotic properties in vivo. Xu, F*, Davis, J* and Van Nostrand, WE*, Thrombosis Research 155:58-64 (2017)
Cerebral vascular amyloid seeds drive amyloid b-protein fibril assembly with a distinct anti-parallel structure. Xu, F*, Fu, Z, Dass, S, Kotarba, AE, Davis, J*, Smith, SO and Van Nostrand, WE*. Nature Communications 7:13527 (2016). PMID: 27869115
Ou-Yang, M., Xu, F., Liao, M.-C., Davis, J., Robinson, J.K., and Van Nostrand, W.E. The N-terminal region of myelin basic protein reduces fibrillar amyloid b-protein deposition in Tg-5xFAD mice. Neurobiology of Aging 36:801-811 (2015) NIHMS635006
Fu, Z., Aucoin, D.S., Davis, J., Van Nostrand, W.E., and Smith, S.O. Mechanism of nucleated conformational conversion of Ab42. Biochemistry 54:4197-4207 (2015)
Xu, W., Xu, F., Anderson, M.E., Kotarba, A.E., Davis, J., Robinson, J.K., and Van Nostrand, W.E. Cerebral microvascular rather than parenchymal amyloid b-protein pathology promotes early cognitive impairment in transgenic mice. Journal of Alzheimer’s Disease 38:621-632 (2014)
Xu, F., Kotarba, A.E., Ou-Yang, M.H., Fu, Z., Davis, J., Smith, S.O., and Van Nostrand, W.E. Early-onset formation of parenchymal plaque amyloid abrogates cerebral microvascular amyloid accumulation in transgenic mice. Journal of Biological Chemistry 289:17895-17908 (2014)
Fu, Z., Aucoin, D., Ahmed, M., Ziliox, M., Van Nostrand, W.E., and Smith, S.O. Capping of Ab42 oligomers by small molecule inhibitors. Biochemistry 53: 7893-7903 (2014)
Kotarba, A., Aucoin, D., Hoos, M.D., Smith, S.O., and Van Nostrand, W.E. Fine mapping of the amyloid b-protein binding site on myelin basic protein. Biochemistry 52:2565-2573 (2013)