The Van Nostrand Lab

Room 360–370, Avedisian Hall

Recent Publications

Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia. Zhu X*, Schrader JM*, Irizarry B, Smith SO, Van Nostrand WE. Biomedicines. November 2022.

Impact of non-pharmacological chronic hypertension on a transgenic rat model of cerebral amyloid angiopathy. Stanisavljevic A*, Schrader JM*, Zhu X*, Mattar JM*, Hanks A*, Xu F*, Majchrzak M*, Robinson JK*, Van Nostrand WE*. Frontiers in Neuroscience, March 2022.

Elevated expression of urokinase plasminogen activator in rodent models and patients with cerebral amyloid angiopathy. Vervuurt M, Zhu X, Schrader J, de Kort A, Marques TM, Kersten I, Kuiperji HB, Klijn CJM, Van Nostrand WE*, and Verbeek MM. Neuropathology and Applied Neurobiology, March 2022. 

rTg-D: A novel transgenic rat model of cerebral amyloid angiopathy type-2. Davis J, Xu F, Zhu X, and Van Nostrand WE. Cerebral Circulation – Cognition and Behavior, March 2022.  

Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries.Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand WE, Benveniste H. Nature Aging, February 2022.  

Emergent white matter degeneration in the rTg-DI rat model of cerebral amyloid angiopathy exhibits unique proteomic changesSchrader JM*, Xu F*, Lee H, Barlock B, Benveniste H, Van Nostrand WE*. American Journal of Pathology, December 2021.  

Normal cerebrospinal fluid concentrations of PDGFRβ in patients with cerebral amyloid angiopathy and Alzheimer’s disease. De Kort AM, Kuiperij HB, Kersten I, Versleijen AAM, Schreuder FHBM, Van Nostrand WE*, Greenberg SM, Klijn CJM, Claassen JAHR, Verbeek MM. Alzheimer’s & Dementia, December 2021.  

Human cerebral vascular amyloid contains both antiparallel and parallel in-register Aβ40 fibrils. Irizarry BA, Davis J*, Zhu X*, Boon BDC, Rozemuller AJM, Van Nostrand WE*, Smith SO. Journal of Biological Chemistry, November 2021.  

Distinct brain regional proteome changes in the rTg-DI rat model of cerebral amyloid angiopathy. Schrader JM*, Xu F*, Van Nostrand WE*. Journal of Neurochemistry, October 2021.  

Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy. Lee H, Xu F*, Liu X, Koundal S, Zhu X*, Davis J*, Yanez D, Schrader J*, Stanisavljevic A*, Rothman DL, Wardlaw J, Van Nostrand WE*, Benveniste H. Journal of Cerebral Blood Flow and Metabolism, May 2021.  

Anti-Parallel β-Hairpin Structure in Soluble Aβ Oligomers of Aβ40-Dutch and Aβ40-Iowa. Ziao F, Van Nostrand WE*, Smith SO. International Journal of Molecular Science, January 2021.  

Selected Past Publications

Metabolomics biomarker discovery in cerebrospinal fluid for cerebral amyloid angiopathy. Van den Berg E, Kuiperij HB, Van Nostrand WE*, Peters TMA, Coene KLM, Engelke UFH, De Boer S, Verbeek MM. Alzheimer’s & Dementia, December 2020. Wiley.

Copper stabilizes antiparallel Beta-sheet fibrils of Ab40-Iowa in vascular amyloid. Crooks E, Ziliox M, Kawakami T, Victor T, Xu F*, Hojo H, Chiu K, Simmerling C, Van Nostrand WE*, Smith SO, and Miller L. Journal of Biological Chemistry, May 2020.

Robust neuroinflammation and perivascular pathology in rTg-DI rats, a novel model of microvascular cerebral amyloid angiopathy. Zhu X*, Hatfield J*, Sullivan JK*, Xu F*, Van Nostrand WE*. Journal of Neuroinflammation, March 2020. PubMed.

Longitudinal Cognitive Decline in a Novel Rodent Model of Cerebral Amyloid Angiopathy Type-1. Popescu D*, Van Nostrand WE*, Robinson J*. International Journal of Molecular Science. March 2020. PubMed.

Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques. Zhu X*, Victor T, Ambi A, Sullivan JK*, Hatfield J*, Xu F*, Miller LM, Van Nostrand WE*. Metallomics, February 2020. PubMed.

Voluntary wheel running reduces amyloid-β42 and rescues behavior in aged Tg2576 mouse model of Alzheimer’s Disease. Francis N*, Robison LS, Popescu DL, Michaelos M, Hatfield J*, Xu F*, Zhu X*, Davis J*, Anderson ME, Anderson BJ, Van Nostrand WE*, Robinson JK*. Journal of Alzheimers Disease, 2020. PubMed. 

Reduced levels of cerebrospinal fluid/plasma Aβ40 as an early biomarker for cerebral amyloid angiopathy in RTg-DI rats. Zhu X*, Xu F*, Hoos MD, Lee H, Benveniste H, and Van Nostrand WE*. International Journal of Molecular Science, 2020. MDPI.

Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy. Robison SL, Popescu DL*, Anderson ME, Francis N, Hatfield J, Sullivan JK, Beigelman SI, Xu F*, Anderson BJ, Van Nostrand WE*, Robinson JK*. Journal of Neuroinflammation, July 2019. PubMed.

Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling. Chen CD, Zeldich E, Khodr C, Camara K, Tung TY, Lauder EC, Mullen P, Polanco TJ, Liu Y-Y, Zeldich D, Xia W, Van Nostrand WE*, Brown LE, Porco JA, Abrahama CR. Journal of Alzheimer’s Disease, July 2019. PubMed.

A novel transgenic rat model of robust cerebral miscrovascular amyloid with prominent vasculopathy. Davis, J*, Xu, F*, Hatfield, J*, Lee H., Hoos, M.D., Popescu, D, Crooks, E., Kim, R*, Smith, S.O., Robinson, JK*, Benveniste, H., and Van Nostrand, WE*  American Journal of Pathology 188:2877-2889, December 2018. PubMed.

Intensive “brain training” intervention fails to reduce amyloid pathologies or cognitive deficits in transgenic mouse models of Alzheimer’s disease. Anderson, M, Xu, F*, Ou-Yang, MH, Davis, J*, Van Nostrand, WE*, and Robinson, JK.* Journal of Alzheimer’s Disease 55:1109-1121(2017). PMID: 27767989

Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid b-protein precursor abolishes its anti-thrombotic properties in vivo. Xu, F*, Davis, J* and Van Nostrand, WE*, Thrombosis Research 155:58-64 (2017)

Cerebral vascular amyloid seeds drive amyloid b-protein fibril assembly with a distinct anti-parallel structure. Xu, F*, Fu, Z, Dass, S, Kotarba, AE, Davis, J*, Smith, SO and Van Nostrand, WE*. Nature Communications 7:13527 (2016). PMID: 27869115

Ou-Yang, M., Xu, F., Liao, M.-C., Davis, J., Robinson, J.K., and Van Nostrand, W.E. The N-terminal region of myelin basic protein reduces fibrillar amyloid b-protein deposition in Tg-5xFAD mice. Neurobiology of Aging 36:801-811 (2015) NIHMS635006

Fu, Z., Aucoin, D.S., Davis, J., Van Nostrand, W.E., and Smith, S.O. Mechanism of nucleated conformational conversion of Ab42. Biochemistry 54:4197-4207 (2015)

Xu, W., Xu, F., Anderson, M.E., Kotarba, A.E., Davis, J., Robinson, J.K., and Van Nostrand, W.E. Cerebral microvascular rather than parenchymal amyloid b-protein pathology promotes early cognitive impairment in transgenic mice. Journal of Alzheimer’s Disease 38:621-632 (2014)

Xu, F., Kotarba, A.E., Ou-Yang, M.H., Fu, Z., Davis, J., Smith, S.O., and Van Nostrand, W.E. Early-onset formation of parenchymal plaque amyloid abrogates cerebral microvascular amyloid accumulation in transgenic mice. Journal of Biological Chemistry 289:17895-17908 (2014)

Fu, Z., Aucoin, D., Ahmed, M., Ziliox, M., Van Nostrand, W.E., and Smith, S.O. Capping of Ab42 oligomers by small molecule inhibitors. Biochemistry 53: 7893-7903 (2014)

Kotarba, A., Aucoin, D., Hoos, M.D., Smith, S.O., and Van Nostrand, W.E. Fine mapping of the amyloid b-protein binding site on myelin basic protein. Biochemistry 52:2565-2573 (2013)