What role do the brain blood vessels play in the development and progression of Alzheimer’s disease and related disorders? 

The Van Nostrand lab investigates the pathogenesis of Alzheimer’s disease, cerebral amyloid angiopathy, and cerebral small vessel disease using biochemical, molecular, cellular, and animal model approaches. Their preclinical models of disease have been used widely to study disease processes, develop biomarkers, and test therapeutic interventions for Alzheimer’s disease and related disorders.

In collaboration with the Robinson lab, the Van Nostrand lab has advanced the understanding of how modifiable lifestyle factors, including diet, physical activity, and cognitive training, can modify genetic predisposition for Alzheimer’s disease.