The Quinlan Lab

Room 470, Beaupre Center for Chemical & Forensic Sciences

* Denotes Quinlan lab affiliation

Selected Publications

Facilitation of sensory transmission to motoneurons during cortical or sensory evoked primary afferent depolarization (PAD) in humans.Metz K et al (incl. Quinlan KA*). Journal of Physiology. March 2023.

Inhibitory interneurons show early dysfunction in a SOD1 mouse model of amyotrophic lateral sclerosis. Cavarsan CF*, Steele PR*, Genry LT*, Reedich EJ*, McCane LM, LaPre KJ*, Puritz AC, Manuel M*, Katenka N, Quinlan KA*. Journal of Physiology. February 2023. (Editor’s Pick)

Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons. Zaida A et al (including Quinlan KA*). Cell Stem Cell. January 2023.

Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy. Reedich EJ*, Genry LT*, Singer MA, Cavarsan CF*, Avila EM*, Boudreau DM*, Brennan MC, Garrett AM, Dowaliby L*, Detloff MR, Quinlan KA*. Journal of Neuroscience Research, July 2022.

Estimation of self-sustained activity from persistent inward currents using firing rate profiles of multiple motor units in humans. Afsharipour B, Manzur N, Duchcherer J, Fenrich KF, Thompson CK, Negro F, Quinlan KA*, Bennett DJ, and Gorassini MA. Journal of Neurophysiology, May 2020.

Altered Motoneuron Properties Contribute to Motor Deficits in a Rabbit Hypoxia-Ischemia Model of Cerebral Palsy. Steele PR*, Cavarsan CF*, Dowaliby L*, Westefeld M*, Katenka N, Drobyshevsky A, Gorassini M, Quinlan KA*. Frontiers in Cellular Neuroscience, March 2020. 

Hyperexcitability precedes motoneuron loss in the Smn2B/-mouse model of spinal muscular atrophy. Quinlan KA*, Reedich E, Arnold WD, Puritz A, Cavarsan CF*, Heckman CJ, DiDonato CJ. Journal of Neurophysiology, July 2019. PubMed.

Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy. Cavarsan CF*, Gorassini MA, Quinlan KA*. Journal of Neurophysiology, September 2019. PubMed.

Dissecting the functional consequences of de novo DNA methylation dynamics in human motor neuron differentiation and physiology. Ziller, M.J. et al. Cell Stem Cell 22, 1–16 (2018).

Chronic EMGs in treadmill running SOD1 mice reveal early changes in muscle activation. Quinlan, KA* et al. J Physiol 595, 5387–5400 (2017).

Spinal cord injury in hypertonic newborns after antenatal hypoxia-ischemia in rabbit cerebral palsy model. Drobyshevsky, A. and Quinlan, KA*.  Exp Neurol 293, 13–26 (2017).

Comparison of dendritic calcium transients in juvenile wild type and SOD1G93A mouse lumbar motoneurons. Quinlan, KA* et al. Front Cell Neurosci 9, 139 (2015).

Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction. Gogliotti, R et al. J Neurosci 32, 3818–3829 (2012).

Electrophysiological and molecular contributions to ALS pathology. Quinlan, KA* Integr Comp Biol 51, 913–25 (2011).

Altered postnatal maturation of electrical properties in spinal motoneurons in an ALS mouse model. Quinlan, KA* et al. J Physiol 589, 2245–60 (2011).

Genetic Ablation of V2a Ipsilateral Interneurons Disrupts Left-Right Locomotor Coordination in Mammalian Spinal Cord. Crone, SA, Quinlan, KA*. (equal authorship) et al. Neuron 60, 70–83, (2008).

Cellular and synaptic actions of acetylcholine in the lamprey spinal cord. Quinlan, KA* (corresponding author) and Buchanan, J.T. J Neurophysiol 100, 1020–1031 (2008).