The Alber Lab

Butler Hospital Memory and Aging Program

For a complete list of publications, click here.

Selected Publications

Alber J, Bouwman F, den Haan J, Rissman RA, De Groef L, Koronyo-Hamaoui M, Lengyel I, Thal DR. Retina pathology as a target for biomarkers for Alzheimer’s disease: Current status, ophthalmopathological background, challenges, and future directions. Alzheimers Dement. 2024 Jan;20(1):728-740. doi: 10.1002/alz.13529. Epub 2023 Nov 2. PubMed PMID: 37917365.

Arthur E, Ravichandran S, Snyder PJ, Alber J, Strenger J, Bittner AK, Khankan R, Adams SL, Putnam NM, Lypka KR, Piantino JA, Sinoff S. Retinal mid-peripheral capillary free zones are enlarged in cognitively unimpaired older adults at high risk for Alzheimer’s disease. Alzheimers Res Ther. 2023 Oct 12;15(1):172. doi: 10.1186/s13195-023-01312-8. PubMed PMID: 37828548; PubMed Central PMCID: PMC10568786.

Lee AKW, Collier MK, Thompson LI, Popescu D, Arthur E, Correia S, Salloway SP, Alber J. The Effects of Subjective Cognitive Decline on APOE Genotype Disclosure in the Butler Hospital Alzheimer’s Prevention Registry. J Prev Alzheimers Dis. 2023;10(2):152-161. doi: 10.14283/jpad.2023.12. PubMed PMID: 36946441.

Mozdbar S, Alber J, Aryal S, Johnson L, Moroz A, Rashik M, Mostafavi A, O’Bryant S. Cognitive dysfunction and the 25-item National Eye Institute Visual Function Questionnaire. Alzheimers Dement (Amst). 2022;14(1):e12378. doi: 10.1002/dad2.12378. eCollection 2022. PubMed PMID: 36407937; PubMed Central PMCID: PMC9667118.

Cersonsky TEK, Mechery S, Thompson L, Lee A, Alber J, Sarkar IN, Brick LAD. Related amyloid burden and cortical atrophy in individuals with subtle cognitive decline. J Neuroimaging. 2022 Nov;32(6):1075-1079. doi: 10.1111/jon.13055. Epub 2022 Sep 23. PubMed PMID: 36151065; PubMed Central PMCID: PMC9903200.

Cersonsky TEK, Mechery S, Carper MM, Thompson L, Lee A, Alber J, Sarkar IN, Brick LAD. Using the Montreal cognitive assessment to identify individuals with subtle cognitive decline. Neuropsychology. 2022 Jul;36(5):373-383. doi: 10.1037/neu0000820. Epub 2022 May 5. PubMed PMID: 35511561; PubMed Central PMCID: PMC9912279.

Alber J, Popescu D, Thompson LI, Tonini GM, Arthur E, Oh H, Correia S, Salloway SP, Lee AK. Safety and Tolerability of APOE Genotyping and Disclosure in Cognitively Normal Volunteers From the Butler Alzheimer’s Prevention Registry. J Geriatr Psychiatry Neurol. 2022 May;35(3):293-301. doi: 10.1177/0891988721993575. Epub 2021 Feb 8. PubMed PMID: 33550928.

Jutten RJ, Thompson L, Sikkes SAM, Maruff P, Molinuevo JL, Zetterberg H, Alber J, Faust D, Gauthier S, Gold M, Harrison J, Lee AKW, Snyder PJ. A Neuropsychological Perspective on Defining Cognitive Impairment in the Clinical Study of Alzheimer’s Disease: Towards a More Continuous Approach. J Alzheimers Dis. 2022;86(2):511-524. doi: 10.3233/JAD-215098. Review. PubMed PMID: 35124638.

Ngolab J, Donohue M, Belsha A, Salazar J, Cohen P, Jaiswal S, Tan V, Gessert D, Korouri S, Aggarwal NT, Alber J, Johnson K, Jicha G, van Dyck C, Lah J, Salloway S, Sperling RA, Aisen PS, Rafii MS, Rissman RA. Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) trial. Alzheimers Dement (Amst). 2021;13(1):e12199. doi: 10.1002/dad2.12199. eCollection 2021. PubMed PMID: 34430703; PubMed Central PMCID: PMC8369843.

Arthur E, Alber J, Thompson LI, Sinoff S, Snyder PJ. OCTA reveals remodeling of the peripheral capillary free zones in normal aging. Sci Rep. 2021 Aug 2;11(1):15593. doi: 10.1038/s41598-021-95230-0. PubMed PMID: 34341456; PubMed Central PMCID: PMC8329222.

Alber J, Arthur E, Goldfarb D, Drake J, Boxerman JL, Silver B, Ott BR, Johnson LN, Snyder PJ. The relationship between cerebral and retinal microbleeds in cerebral amyloid angiopathy (CAA): A pilot study. J Neurol Sci. 2021 Apr 15;423:117383. doi: 10.1016/j.jns.2021.117383. Epub 2021 Mar 1. PubMed PMID: 33684655.

Snyder PJ, Alber J, Alt C, Bain LJ, Bouma BE, Bouwman FH, DeBuc DC, Campbell MCW, Carrillo MC, Chew EY, Cordeiro MF, Dueñas MR, Fernández BM, Koronyo-Hamaoui M, La Morgia C, Carare RO, Sadda SR, van Wijngaarden P, Snyder HM. Retinal imaging in Alzheimer’s and neurodegenerative diseases. Alzheimers Dement. 2021 Jan;17(1):103-111. doi: 10.1002/alz.12179. Epub 2020 Oct 8. Review. PubMed PMID: 33090722; PubMed Central PMCID: PMC8062064.

Alber J, Arthur E, Sinoff S, DeBuc DC, Chew EY, Douquette L, Hatch WV, Hudson C, Kashani A, Lee CS, Montaquila S, Mozdbar S, Cunha LP, Tayyari F, Van Stavern G, Snyder PJ. A recommended “minimum data set” framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer’s Study (ARIAS). Alzheimers Dement (Amst). 2020;12(1):e12119. doi: 10.1002/dad2.12119. eCollection 2020. PubMed PMID: 33163610; PubMed Central PMCID: PMC7604454.

Alber J, Maruff P, Santos CY, Ott BR, Salloway SP, Yoo DC, Noto RB, Thompson LI, Goldfarb D, Arthur E, Song A, Snyder PJ. Disruption of cholinergic neurotransmission, within a cognitive challenge paradigm, is indicative of Aβ-related cognitive impairment in preclinical Alzheimer’s disease after a 27-month delay interval. Alzheimers Res Ther. 2020 Mar 24;12(1):31. doi: 10.1186/s13195-020-00599-1. PubMed PMID: 32209123; PubMed Central PMCID: PMC7093953.

Alber J, Goldfarb D, Thompson LI, Arthur E, Hernandez K, Cheng D, DeBuc DC, Cordeiro F, Provetti-Cunha L, den Haan J, Van Stavern GP, Salloway SP, Sinoff S, Snyder PJ. Developing retinal biomarkers for the earliest stages of Alzheimer’s disease: What we know, what we don’t, and how to move forward. Alzheimers Dement. 2020 Jan;16(1):229-243. doi: 10.1002/alz.12006. PubMed PMID: 31914225.

Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers Dement (N Y). 2019;5:107-117. doi: 10.1016/j.trci.2019.02.001. eCollection 2019. Review. PubMed PMID: 31011621; PubMed Central PMCID: PMC6461571.

Alber J, McGarry K, Noto RB, Snyder PJ. Use of Eflornithine (DFMO) in the Treatment of Early Alzheimer’s Disease: A Compassionate Use, Single-Case Study. Front Aging Neurosci. 2018;10:60. doi: 10.3389/fnagi.2018.00060. eCollection 2018. PubMed PMID: 29559907; PubMed Central PMCID: PMC5845715.

Santos CY, Snyder PJ, Wu WC, Zhang M, Echeverria A, Alber J. Pathophysiologic relationship between Alzheimer’s disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis. Alzheimers Dement (Amst). 2017;7:69-87. doi: 10.1016/j.dadm.2017.01.005. eCollection 2017. Review. PubMed PMID: 28275702; PubMed Central PMCID: PMC5328683.

Alber J, Lee AKW, Menard W, Monast D, Salloway SP. Recruitment of At-Risk Participants for Clinical Trials: A Major Paradigm Shift for Alzheimer’s Disease Prevention. J Prev Alzheimers Dis. 2017;4(4):213-214. doi: 10.14283/jpad.2017.32. PubMed PMID: 29181484.

Snyder PJ, Johnson LN, Lim YY, Santos CY, Alber J, Maruff P, Fernández B. Nonvascular retinal imaging markers of preclinical Alzheimer’s disease. Alzheimers Dement (Amst). 2016;4:169-178. doi: 10.1016/j.dadm.2016.09.001. eCollection 2016. PubMed PMID: 27830174; PubMed Central PMCID: PMC5078641.

Dewar M, Alber J, Cowan N, Della Sala S. Boosting long-term memory via wakeful rest: intentional rehearsal is not necessary, consolidation is sufficient. PLoS One. 2014;9(10):e109542. doi: 10.1371/journal.pone.0109542. eCollection 2014. PubMed PMID: 25333957; PubMed Central PMCID: PMC4198139.

Alber J, Della Sala S, Dewar M. Minimizing interference with early consolidation boosts 7-day retention in amnesic patients. Neuropsychology. 2014 Sep;28(5):667-75. doi: 10.1037/neu0000091. Epub 2014 May 12. PubMed PMID: 24819064.

Dewar M, Alber J, Butler C, Cowan N, Della Sala S. Brief wakeful resting boosts new memories over the long term. Psychol Sci. 2012 Sep 1;23(9):955-60. doi: 10.1177/0956797612441220. Epub 2012 Jul 24. PubMed PMID: 22829465.