Seminar: The Impact of DNA Methylation on Neuropathology: Understanding Disease and Searching for Biomarkers
Paula Desplats, Ph.D.
Assistant Professor of Neurosciences and of Pathology University of California San Diego School of Medicine San Diego, CA
Parkinson’s and Alzheimer’s diseases are the most prevalent neurodegenerative disorders in the aging population and their incidence is growing exponentially. The multifactorial etiology of these diseases encumbers the development of improved therapeutic strategies to eventually cure them. Emerging evidence now supports the involvement of epigenetic mechanisms in neurodegeneration, adding a new layer of complexity to pathology. However, the mechanisms that contribute to alterations in DNA methylation and its role in disease trajectory remain poorly understood. Research at the Desplats lab combines basic mechanistic studies and translational research to investigate the dynamics of DNA methylation that may be associated with disease, including the role of methylation on circadian impairment in Alzheimer’s disease, as well as the exploration of the potential of methylation as a novel biomarker for the diagnosis of Parkinson’s disease and related disorders.
Dr. Desplats is a candidate for Associate Professor in the George & Anne Ryan Institute for Neuroscience.
Wednesday, April 5, 2017
Room 240, College of Pharmacy